Science & Engineering: Electronic Medical Records, Big Data in Healthcare & More

[04.14.15]

Science & Engineering News: Electronic Medical Records, Big Data in Healthcare & More

Digital Medicine & Digital Healthcare: Electronic Medical Records (EMR)

“In one month, the electronic monitors in our five intensive care units, which track things like heart rate and oxygen level, produced more than 2.5 million alerts. It’s little wonder that health care providers have grown numb to them. [Health parameter Tuning]

… Improvements will come with refinement of the software. Today’s health care technology has that Version 1.0 feel, and it is sure to get better.

… Changes in the work force and culture … federal policies that promote the seamless sharing of data between different systems in different settings … Reimagine how our work can be accomplished in a digital environment.”

Digital Medicine & Digital Healthcare: Big Data

“Big-data efforts under way in health care include Optum Labs, a collaboration between UnitedHealth Group and the Mayo Clinic, in which researchers mine clinical and insurance data in search of micro-patterns that give clues to early indicators of disease and help to tailor treatments.

Precision Medicine, an initiative announced by President Barack Obama earlier this year, will combine genetic data with information from fitness trackers.”

Electronic Medical Records (EMR) & Molecular Medicine #AtMyVentures

#DigitalMedicine  #MolecularMedicine

  1. Database Interoperability: What is required: Common Standards & Protocols. Medical Database Ontology. Future Scenario: Whichever Physician you choose, your Doctor can instantly access all your previous Health records; provided, you give permission to the Doctor (on a selective basis if you want to keep some of your records Private – “The Privacy Factor”). Plus Privacy from Insurance Companies.
  2. Cloud Storage: So that any healthcare provider can access patient record.
  3. Health Parameter Tuning: So that EMR generate accurate alerts.
  4. Personalized Medicine: Personalized Medicine will be “adaptive” in the sense that the EMR system will “continuously” monitor and tune dosages of drugs, etc and hence “personalize” treatment for each individual patient.  
  5. Merging of Medical Big Data & Molecular Medicine: Molecular Medicine will reach a point when Doctors can adapt treatments and predict in advance the effects (in body) of dosage changes “accurately”.

Engineering & Sciences: Biotech & More

 

Engineering & Sciences: Biotech & More

[03.24.15]

 

Biotech Ventures

“The wider change is that biology is getting cheaper and easier to do.”

Science & Engineering, Medicine & Innovation: IoT, Microsoft & More

 

Science & Engineering, Medicine & Innovation: IoT, Microsoft & More

Drug Development #Medicine #BioEngineering

Microsoft

Structure of Medicine & BioEngineering Ventures

Structure of Medicine & BioEngineering “Ventures”

#AtMyVentures

[I’ll start each of the 11 Units from scratch; no acquisitions.

Finance for Space. Hiring. Instruments: Manufactured@MyVentures.

Start: with marketable Products & Services (Units 1, 2, 3, 4 & 6) and bootstrapping from there.]

[Unit 1, 2, 3 & 4: Gadgets, Instruments & Healthcare Systems]

Unit 1: Digital Medicine & Digital Healthcare

Electronic Medical Record (EMR) Platform”

Mobile Health Gadgets. “Wearables”. Personal Medical Agent (on Smartphone, Tabs, etc.).

E-Health & M-Health [Developing Nations; Shortage of Physicians & Healthcare Providers].

Preventive Medical Service Delivery. 

Expert Diagnostic System. Decision Support System. AI.

Unit 2: Medical & Diagnostic Gadgets

Ultrasound. MRI & PET Scanner.

X-Ray & CT Scanner.

Laser. Colonoscopy. Pacemaker. Blood Testing Service.

Unit 3: Engineering & Consulting Services to Hospitals & Clinics

Hospital / Clinic Design: Emergency Care.

Training: Physicians, Nurses, Medical Assistants & Medical Technologists [jointly with “Education Ventures”]

Genome Sequencing Services. Gene Therapy Procedures. Molecular Medicine.

“AI Platform” for Physicians (Assistance with Diagnosis, Treatment Planning, Search, etc.).

Robotic Service Providers (at Hospitals). Robo-Nurses. Tele-Medicine.

Unit 4: Engineering & Consulting Services to Biotech – Bioengineering – BioPharma Industry

Drug “Manufacturing Facility” Development.

Research Equipment (used in Biotech & Bio-Pharma Industry). Example: Genome Sequencers.

[Unit 5 & 6: Medicine & Surgery]

Unit 5: Pharmaceuticals & Medicine [Core Bio]

Drug Development.

Drug Delivery System Development.

Unit 6: Surgical Procedures & Instruments [Gadgets, Instruments, Surgical Procedures]

Surgical Procedures. Imaging Tools.

Endoscopic Surgical Tools. 

Robotic Surgical Systems.

[Unit 7, 8 & 9: Study of Life – The Frontiers]

Unit 7: Core Bio & Molecular Medicine

Genome Sequencing. Gene Therapy Development. Gene Editing. 

Molecular Medicine.

Microbiome & Microbiology.

Stem Cell Research. Tissue Engineering. Regenerative Medicine.

Bio-Materials. Nano-Biotechnology.

Unit 8: Computational & Systems Biology

Modeling of Life & Living Systems.

Bioinformatics. Computational Biology. Systems Biology.

Computational Bio-Mechanics (Applicable to Sports Science).

Unit 9: Brain & Mind

Neurological Disorders.

Psychiatric Disorders.

Computational Neuroscience.

Neuro-Engineering: Artificial Retina. Electrode Implant. Prosthetics.

Unit 10: Preventive Medicine & Well-being

Child rearing: IQ, Creativity, Character Development, Health.

Adolescent Guidance.

Exercise & Nutrition. Food & Nutrition Research. Exercise Physiology Research.

Unit 11: Disease / Disability Focus

Separate Units / Sub-units:

Cancer. AIDS. Autism. Parkinson’s. Alzheimer’s. Motor Neuron. Cardiovascular Diseases. Cerebrovascular Diseases.

Infectious Diseases, Epidemics & Public Health.

Possible HQ Locations: Boston, Massachusetts. California. London.

Science & Engineering, Medicine & Innovation: “Jurassic” Theme Park, Physical Digital Retail & More

 

Science & Engineering, Medicine & Innovation: “Jurassic” Theme Park, Physical Digital Retail & More

Bio-Electronic Medicine 

#BioEngineering #Medicine #MolecularMedicine

“Stimulation of the nervous system could replace drugs for inflammatory and autoimmune conditions”

 

Paleontology – Molecular Biology 

“Jurassic” Theme Park

#ThemeParkDevelopment #BioEngineering #MolecularBio #Biotechnology  #Paleontology

 

Has Science advanced to the point when it can enable us create “Jurassic” Theme Parks featuring Dinosaurs?

“A father-son duo of biologists has set the stage for so-called de-extinction.”

 

 

Computational Neuroscience & Neuro-Engineering  

#ComputationalNeuroscience #NeuroEngineering #Neuroscience #CognitiveScience

 

Google  #PhysicalDigitalRetail

 

Physical Digital Retail  #PhysicalDigitalRetail

 

Frontiers Of Engineering & Technology

Frontiers Of Engineering & Technology : Research & Engineering (R&E)

Energy & Power

Energy & Power: Materials for Solar

Energy & Power: Decentralized Power Grid

Energy & Power: Smart Solar, Smart Wind

Artificial Intelligence

Artificial Intelligence : Machine Learning

Robotics

Robotics: Augmented Robotics; Service Robotics 

Robotics: Drone / Unmanned Aerial Vehicle (UAV)

Robotics: Agile Robotics

Medicine & BioEngineering

Medicine & BioEngineering: Computational & Systems Biology

Medicine & BioEngineering: Genomics, Molecular Biology & Molecular Medicine

 

Computational Neuroscience & NeuroEngineering

Computational Neuroscience

Latest From Science & Engineering, Medicine & Innovation [02.24.15]

BioEngineering   Biotech

“As a drug, an mRNA would supply the biological instructions for producing a protein inside cells.

Therapeutic gene-silencing RNAs inhibit damaging proteins from being made in the body.

Hurdles: Innate immune response. Unstable Molecule.”

 

“Venture capital investment in U.S. life sciences companies (Second biggest category for venture investment after software) soared 29 percent in 2014 from the year before, reaching $8.6 billion, the highest level since 2007.”

 

Big Data

“Data mining Wikipedia people reveals some surprising differences in the way eastern and western cultures identify important figures in history, say computational anthropologists.

The top five in the English language version are George W Bush, William Shakespeare, the Victorian biographer Sidney Lee, Jesus Christ and Charles II of England.”

Current Stage Of Genomics & “Molecular Medicine” Research & The Future

Current Stage Of Genomics & “Molecular Medicine” Research & The Future

 

The current stage of Genomics is:

So we have people with a certain Disorder (say, “X”).

Let’s gather Genomic Data of as many persons as we can with “X” Disorder and find similarities in their Genomes to find out which “Gene”s could be responsible for the “X” Disorder.

This approach is limited.

To see why, let’s go through a quick lesson in Biology.

 

All of the Cells in our body have the same DNA.

But a Cell in our “Heart” behaves differently than a Cell in “Skin”.

The Genetic Material is the same, but Behavior is different.

How?

 

Proteins (Transcription Factors) inside the Cell and different elements in the Extra-Cellular Matrix makes the difference.
The “Proteins (Transcription Factors) inside the Cell and elements in the Extra-Cellular Matrix” of Heart Cell is what make it behave differently than a Cell in your Skin.

All of our Cells contain the identical Genetic Material to the first Cell that made us.
“Differential Gene Expression” is how that Cell gradually turned into the Cells of Skin, Heart, Pancreas, etc.

Now, suppose a person say, “A” has a certain disorder / disability say, “D”.

Suppose, the “D” disorder makes “A”‘s Motor Neurons shrink with time.

It would be “of limited view” to try to find out “the Gene” responsible for the disorder “D”.

Because each “Gene” that expresses itself through “Proteins” effects our body in different ways depending on in which part of the body the Protein is acting.

A particular “Gene” say, “G1” encoding certain Protein in our “Skin cell” might have different effect than

the same “G1” Gene encoding the same “Protein” (but involved in a different “Gene Regulatory Network”) in our “Motor Neuron”.

A better approach is to consider the effect of “Network of Genes” involved in a certain “Gene Regulatory Network”.

“Network of Genes” involved in different “Gene Regulatory Network”s express themselves to structure our Phenotype (and also our “Disorders” and “Disabilities”).

 

As we can see, Biologists should always keep in mind that:

“It’s not a single Gene that cause a certain Disorder, but ‘A Network of Genes’ involved in a certain “Gene Regulatory Network” that do.”

 

“A Network of Genes” translated into Proteins 

(a Protein itself could be defective or it could be “A wrong set of Proteins”) 

interacting in less-than-normal ways with other Proteins and Molecules

– From a macro perspective we classify this misbehavior as one of the (already classified) Disorders.

 – This is a “Molecular definition” of Diseases and Disorders.

#MolecularMedicine

 

Then why do Biologists approach “Molecular Medicine” this way (the Current approach):

“Let’s gather Genomic Data of as many persons as we can with “X” disorder and find similarities in their Genomes to find out which “Gene”s could be responsible for the “X” disorder”

The reason: Biology as a Science, is yet to mature.
Biologists still struggle to find out which Genes encode which Protein with a certain feature.

 

We are still far from complete understanding of:

Gene ->  Differential Gene Expression ->  Phenotype / Disorder / Disabilities.

Our current approach is to find out:

Gene  ->  Disorder / Disabilities.

“Let’s get as many people as we can with a certain Disorder and search their Genome to find the “Gene” responsible for the “Disorder”.

an approach which, as I have explained, is limited.

 

Areas of Expertise:  

#Molecular Medicine

#Computational & Systems Biology (CSB)

#BioEngineering

#Medicine  #Medical Sciences

Evolution of My Dreams and Realizations

My first ‘Aim in life’, as far as I can remember (It was 1988 / 89; I was 2 or 3), was to become a milkman. I mean, it wasn’t about being a milkman. I wanted to become the honest person appreciated by my parents – a milkman by the name Mubarak. (“I want to become Mubarak”, I used to say). So, what I truly wanted to become was a plain, simple, honest person. 

stock-photo-milkman-94006828

Next, I wanted to become a building mechanic. I used to stare at people who built houses in awe. My uncle sent me a toy Mechanical Tool Box.

My next major change in aim occurred when I wanted to join the Military (age: 4-5). Each night, I used to stay awake until the National Anthem with the National Flag was played on BTV and give salute. I watched a Television program depicting Military life. One of my uncles quipped: “The secret: Tahsin wants to become the President!”.

salute-quotes-6
My mom told me of an incident that took place when I was a baby of few months old (1986). One day, General Ershad was delivering a speech (who was then the President). My mom was studying for her exams. I was lying right beside my maternal Grandfather. My Grandfather suddenly started praying loudly: “God, grant my wish and guide my grandson to become the President and lead the Nation.” My Grandmother called my mom, “Come! Quick! Look how your dad is praying for your son!”     

During my First grade, a serial had an enormous influence on me: “The sword of Tipu Sultan”. Tipu Sultan and Hyder Ali were my childhood heroes. The serial drew me to History. I was deeply influenced by another historical novel during 3rd / 4th Grade – “Khun Ranga Path”. Besides History, books on General Knowledge were among my favorites from an early age. My father bought me my first “General Knowledge” book (Encyclopedia) around 5. Then I discovered “General Knowledge” books (Encyclopedia) in my aunt’s house. Later, I started buying Encyclopedia myself. I used to stare at the Globe of the world and fantasize (
Grade 3 / 4). I fantasized first becoming a King of Ancient Bengal, then King of Myanmar (Burma) and later lifetime President of Kazakhstan. 

I remember playing computer games at one of our relative’s house during Fifth grade. Almost everyone around me wanted to become a Computer Engineer at that time. So I thought I should try to become one myself – a Computer Engineer. 

During my middle school years, I was a voracious reader of novels. Reading novels was the most fun activity I could think of. I could understand different writing techniques employed by novelists. Becoming a novelist, writing great novels was my dream during 7th to 10th grade (1999 – 2002). For living, I would become a Physician or Engineer or Architect. That was my plan.

During 9th / 10th grade, I made up my mind to study Medicine (there was huge encouragement from my parents) and become a Physician besides writing novels.

When I read a book on Psychology (my mom’s book on Educational Psychology from her M.Ed. course), I understood that an intense interest in the workings of the human mind was the chief reason I wanted to become a novelist. Moreover, Literature could only depict subjective human experience, but the objective theories of Psychology applied to all humans.

I thought that I could become a Physician and specialize in Psychiatry or Neurology.

Studying Psychology helped me understand the essence of Science: To understand experimentally provable General Rules that govern everything we see around us.

Studying Psychology books gave me the confidence that: I can come up with original ideas, and that I should question what is written in books.

Trying to understand the theories of Psychology in terms of my own experiences and what I see around me, made me aware of the connection between Real World and the world of Books and Theories.

As I later diversified and ventured into different branches of Science, these realizations and understandings proved invaluable.

One day, as I was preparing for my high school (11th grade) Entrance Exam (later it was decided that Entrance would be based on results of matriculation exam), a Chapter on different forms of Energy from my Physics book grabbed my attention. I thought: maybe I could work on both Psychology / Neurology and Physics. I went through my 9-10th grade Physics book. I bought and read other books (Undergraduate level Physics Textbooks, Stephen Hawkin’s A Brief History of Time and others).

I thought and wrote down my understandings and realizations. I tried to come up with new Theories myself.

Physics taught me to understand “everything” in terms of fundamental constituents and few fundamental laws that govern things we see around us.

Physics made me realize the necessity of learning Higher Mathematics.

Mathematical Olympiad was gaining popularity in Bangladesh at that time (it was 2003). I bought Books and started solving problems.

One of the books published at that time was “নিউরনে অনুরণন” (“Resonance in neurons”). The idea for the name: it’s better to create resonance in your brains’ neurons by solving Mathematical problems rather than leaving the neurons idle!

I found out: the more I worked on problems, the better I could think! My Neurons really were resonating!

My interest in Psychology helped me appreciate brain function improvement and Mathematical Problem Solving. I discovered ways of improving brain function myself.

It was an amazing realization – I could become anyone I wanted if I worked in the right way.

Other Sciences started grabbing my attention.

Psychology drew me to Neuroscience – the Biology of what happens in the mind. Physics led me to Cosmology (the study of the evolution of the Universe) and some of the books described evolution of our planet and Biological evolution. Evolutionary Biology was among my favorites.

At that point, I saw my future as a Scientist: trying to understand the truth and decode the Laws of Nature.

I became interested in Computer Science and Engineering as I read an article portraying the field of Artificial Intelligence. The article was written by Dr. Ali Asgar included in one of his popular science books (Grade 11). I bought Undergrad Texts on Artificial Intelligence and started reading.

Psychology and Neuroscience always grabbed my attention. So when I found out that there is a subfield in CS that tries to emulate intelligence on computers, I got hooked instantly. 

Later, I participated in International Mathematical Olympiad, and met people who were serious participants in programming contests and I felt that I really liked contests and competitions. Besides, computation seem to be everywhere – required in almost every branch. I could do Physics and Biology on Computers. I read an inspirational book (“Medhabi Manusher Golpo” – Prof. Dr Kaykobad) which depicted lives of eminent Computer Scientists and students of Computer Science. The choice was either Physics or Computer Science and Engineering, but my parents wouldn’t let me study Physics. Choosing Computer Science and Engineering also made sense when I considered practical aspects. I thought: I could still pursue my multi-disciplinary interests besides studying CSE at college. 

The Majors I considered at that time included: Computer Science and Engineering, Physics, Mathematics, Neuroscience, Nanotechnology / Nanoengineering & Bioengineering / Biomedical Engineering.

[If you find my life and my understandings interesting you might like Looking back and connecting the dots.]

Lets move a few years forward … During March / April 2013, I thought, I should analyze and understand and learn from and codify everything I see around me – just as I did with the sciences and engineering. I started with the political situation in Bangladesh. I wanted to figure out what would happen if I start my own Political Party. Next, I applied my analysis to other domains: Mechanical Engineering, Economics, Computer Science.

I discovered new thinking tools along the way. Previously, if I found something interesting, I used to look it up on the Web or download a book. But now, whatever I try to understand, first I develop ‘a model’ in my mind just by thinking and then fill out the blanks in my model by asking questions and reading and learning.

15349608_1812528449024359_1986192403384969711_n
I come across new understandings and realizations almost on a daily basis. I look forward to share my newer understandings at sometime in not too distant future: “Living to tell the tale”, truly!
16939627_1856497677960769_8334827596973863688_n

Studying Medicine [Letter to Younger Siblings]

I have always spent a great deal of time on learning “how to learn” and studying “how to study”. #MetaCognition
These days I am jotting my ideas down. I thought about messaging some advice to my brother and sister both of whom are studying Medicine. This is what the advice looked like.


1.  Imagine your Dream coming true. Feel happy! Think how becoming a great Physician can help turn your dreams into reality. (Say to yourself: Yes! I can turn all of my dreams into reality!) Now stop doing everything else and start studying! Motivate yourself regularly.

2. Ignite curiosity. (Say to yourself: hey I understand only a few isolated concepts about how we see things [with eyes]! Now, I really want to understand the Visual System as a whole thoroughly!)
As you read, never lose sight of the concepts you wanted to know and the questions you had in mind – when you started out. As you learn, pose questions to yourself and study-think to find out answers to those questions. Write the questions down if necessary. (Say to yourself: So now I understand how Image forms on the retina, but how does the signal reach the brain?)
Get excited! (Wow! I never knew that there was a primary visual area and a secondary visual area!) Feel proud of yourself! (Say: Yeah! Now I understand the visual system better!) Become passionate!

3. Just as we build model of a person (he is such and such), build Model of each of the systems of Human body and integrate “every” fact and concept you learn to those models.

4. Build models of Systems and Subsystems: Cardiovascular system (subsystem: heart), Nervous system (subsystems: spinal cord, eyes-vision, brain, etc.). Integrate whatever you learn about a system in that system’s model. Visualize – try to see everything in your mind’s eyes. As you learn new concepts, integrate them into respective models. Draw Pictures, Diagrams. Write on those pictures, diagrams.

5. Consider Hierarchy of Systems (how cells make different tissues, tissues make different organs).

6. Learn how Systems Interact (e.g., stress triggers hormonal responses {endocrine system}). Visualize – draw – use graphs/networks (diagrams with lines connecting different systems).

7. While learning pathology, build Models of Diseases. Now model how different systems (cardiovascular, immune) work/dysfunction (as a result of e.g., a particular class of virus / bacteria) to give rise to diseases and the treatment plan. (Say, so this is why the treatment plan for this disease is that!)

8. Can’t find answer to one of your questions? Can’t understand something clearly enough? “Google”!  

9. Never forget to Visualize! When you visualize / draw diagrams, you can take in a lot of information at a time, organize all the knowledge and all the facts you learn seem real.