Science & Engineering: Electronic Medical Records, Big Data in Healthcare & More

[04.14.15]

Science & Engineering News: Electronic Medical Records, Big Data in Healthcare & More

Digital Medicine & Digital Healthcare: Electronic Medical Records (EMR)

“In one month, the electronic monitors in our five intensive care units, which track things like heart rate and oxygen level, produced more than 2.5 million alerts. It’s little wonder that health care providers have grown numb to them. [Health parameter Tuning]

… Improvements will come with refinement of the software. Today’s health care technology has that Version 1.0 feel, and it is sure to get better.

… Changes in the work force and culture … federal policies that promote the seamless sharing of data between different systems in different settings … Reimagine how our work can be accomplished in a digital environment.”

Digital Medicine & Digital Healthcare: Big Data

“Big-data efforts under way in health care include Optum Labs, a collaboration between UnitedHealth Group and the Mayo Clinic, in which researchers mine clinical and insurance data in search of micro-patterns that give clues to early indicators of disease and help to tailor treatments.

Precision Medicine, an initiative announced by President Barack Obama earlier this year, will combine genetic data with information from fitness trackers.”

Electronic Medical Records (EMR) & Molecular Medicine #AtMyVentures

#DigitalMedicine  #MolecularMedicine

  1. Database Interoperability: What is required: Common Standards & Protocols. Medical Database Ontology. Future Scenario: Whichever Physician you choose, your Doctor can instantly access all your previous Health records; provided, you give permission to the Doctor (on a selective basis if you want to keep some of your records Private – “The Privacy Factor”). Plus Privacy from Insurance Companies.
  2. Cloud Storage: So that any healthcare provider can access patient record.
  3. Health Parameter Tuning: So that EMR generate accurate alerts.
  4. Personalized Medicine: Personalized Medicine will be “adaptive” in the sense that the EMR system will “continuously” monitor and tune dosages of drugs, etc and hence “personalize” treatment for each individual patient.  
  5. Merging of Medical Big Data & Molecular Medicine: Molecular Medicine will reach a point when Doctors can adapt treatments and predict in advance the effects (in body) of dosage changes “accurately”.

America In Realization [04.09.15]

 

Law & Justice

“North Charleston Mayor Keith Summey mandates more Police body cameras after shooting of black man.

The shooting in the sprawling industrial city of 104,000 people whose population is 47% black”

Missouri in Realization

Two African-Americans were elected to the Ferguson City Council on Tuesday and will join the existing black member. That means three of the council’s six seats will be held by minority officials—the first time that has happened in its 120-year history.”

– [04.09.15]

Earlier: America In Realization [12.02.14]

“The residents of Ferguson can and should transfer their anger to Politics.

Half of the City Council will be up for election in April.

  • Organizing and nominating a set of candidates,
  • Registering voters and
  • Running election campaigns

is far more exciting and surely the best possible way to bring about lasting change.

Note: Voter turnout in Ferguson has been only 11 percent to 12 percent. For black residents, the number has been even lower.

Let there be increased political awareness and constructive political involvement among American youth.

– [12.02.14]

 

Illinois in Realization

Mayor Rahm Emanuel

Mayor Rahm Emanuel

Business & Economics: BioPharma Industry

 

Foreign Policy: Middle East

“As Tehran focuses on finalizing agreement to lift sanctions, Syrian leader risks losing key ally.

Iran and Russia are willing to envision a solution to the four-year-old conflict in Syria that eventually eases Bashar-Al Assad out of power”

Structure of Medicine & BioEngineering Ventures

Structure of Medicine & BioEngineering “Ventures”

#AtMyVentures

[I’ll start each of the 11 Units from scratch; no acquisitions.

Finance for Space. Hiring. Instruments: Manufactured@MyVentures.

Start: with marketable Products & Services (Units 1, 2, 3, 4 & 6) and bootstrapping from there.]

[Unit 1, 2, 3 & 4: Gadgets, Instruments & Healthcare Systems]

Unit 1: Digital Medicine & Digital Healthcare

Electronic Medical Record (EMR) Platform”

Mobile Health Gadgets. “Wearables”. Personal Medical Agent (on Smartphone, Tabs, etc.).

E-Health & M-Health [Developing Nations; Shortage of Physicians & Healthcare Providers].

Preventive Medical Service Delivery. 

Expert Diagnostic System. Decision Support System. AI.

Unit 2: Medical & Diagnostic Gadgets

Ultrasound. MRI & PET Scanner.

X-Ray & CT Scanner.

Laser. Colonoscopy. Pacemaker. Blood Testing Service.

Unit 3: Engineering & Consulting Services to Hospitals & Clinics

Hospital / Clinic Design: Emergency Care.

Training: Physicians, Nurses, Medical Assistants & Medical Technologists [jointly with “Education Ventures”]

Genome Sequencing Services. Gene Therapy Procedures. Molecular Medicine.

“AI Platform” for Physicians (Assistance with Diagnosis, Treatment Planning, Search, etc.).

Robotic Service Providers (at Hospitals). Robo-Nurses. Tele-Medicine.

Unit 4: Engineering & Consulting Services to Biotech – Bioengineering – BioPharma Industry

Drug “Manufacturing Facility” Development.

Research Equipment (used in Biotech & Bio-Pharma Industry). Example: Genome Sequencers.

[Unit 5 & 6: Medicine & Surgery]

Unit 5: Pharmaceuticals & Medicine [Core Bio]

Drug Development.

Drug Delivery System Development.

Unit 6: Surgical Procedures & Instruments [Gadgets, Instruments, Surgical Procedures]

Surgical Procedures. Imaging Tools.

Endoscopic Surgical Tools. 

Robotic Surgical Systems.

[Unit 7, 8 & 9: Study of Life – The Frontiers]

Unit 7: Core Bio & Molecular Medicine

Genome Sequencing. Gene Therapy Development. Gene Editing. 

Molecular Medicine.

Microbiome & Microbiology.

Stem Cell Research. Tissue Engineering. Regenerative Medicine.

Bio-Materials. Nano-Biotechnology.

Unit 8: Computational & Systems Biology

Modeling of Life & Living Systems.

Bioinformatics. Computational Biology. Systems Biology.

Computational Bio-Mechanics (Applicable to Sports Science).

Unit 9: Brain & Mind

Neurological Disorders.

Psychiatric Disorders.

Computational Neuroscience.

Neuro-Engineering: Artificial Retina. Electrode Implant. Prosthetics.

Unit 10: Preventive Medicine & Well-being

Child rearing: IQ, Creativity, Character Development, Health.

Adolescent Guidance.

Exercise & Nutrition. Food & Nutrition Research. Exercise Physiology Research.

Unit 11: Disease / Disability Focus

Separate Units / Sub-units:

Cancer. AIDS. Autism. Parkinson’s. Alzheimer’s. Motor Neuron. Cardiovascular Diseases. Cerebrovascular Diseases.

Infectious Diseases, Epidemics & Public Health.

Possible HQ Locations: Boston, Massachusetts. California. London.

Science & Engineering, Medicine & Innovation: “Jurassic” Theme Park, Physical Digital Retail & More

 

Science & Engineering, Medicine & Innovation: “Jurassic” Theme Park, Physical Digital Retail & More

Bio-Electronic Medicine 

#BioEngineering #Medicine #MolecularMedicine

“Stimulation of the nervous system could replace drugs for inflammatory and autoimmune conditions”

 

Paleontology – Molecular Biology 

“Jurassic” Theme Park

#ThemeParkDevelopment #BioEngineering #MolecularBio #Biotechnology  #Paleontology

 

Has Science advanced to the point when it can enable us create “Jurassic” Theme Parks featuring Dinosaurs?

“A father-son duo of biologists has set the stage for so-called de-extinction.”

 

 

Computational Neuroscience & Neuro-Engineering  

#ComputationalNeuroscience #NeuroEngineering #Neuroscience #CognitiveScience

 

Google  #PhysicalDigitalRetail

 

Physical Digital Retail  #PhysicalDigitalRetail

 

Frontiers Of Engineering & Technology

Frontiers Of Engineering & Technology : Research & Engineering (R&E)

Energy & Power

Energy & Power: Materials for Solar

Energy & Power: Decentralized Power Grid

Energy & Power: Smart Solar, Smart Wind

Artificial Intelligence

Artificial Intelligence : Machine Learning

Robotics

Robotics: Augmented Robotics; Service Robotics 

Robotics: Drone / Unmanned Aerial Vehicle (UAV)

Robotics: Agile Robotics

Medicine & BioEngineering

Medicine & BioEngineering: Computational & Systems Biology

Medicine & BioEngineering: Genomics, Molecular Biology & Molecular Medicine

 

Computational Neuroscience & NeuroEngineering

Computational Neuroscience

Current Stage Of Genomics & “Molecular Medicine” Research & The Future

Current Stage Of Genomics & “Molecular Medicine” Research & The Future

 

The current stage of Genomics is:

So we have people with a certain Disorder (say, “X”).

Let’s gather Genomic Data of as many persons as we can with “X” Disorder and find similarities in their Genomes to find out which “Gene”s could be responsible for the “X” Disorder.

This approach is limited.

To see why, let’s go through a quick lesson in Biology.

 

All of the Cells in our body have the same DNA.

But a Cell in our “Heart” behaves differently than a Cell in “Skin”.

The Genetic Material is the same, but Behavior is different.

How?

 

Proteins (Transcription Factors) inside the Cell and different elements in the Extra-Cellular Matrix makes the difference.
The “Proteins (Transcription Factors) inside the Cell and elements in the Extra-Cellular Matrix” of Heart Cell is what make it behave differently than a Cell in your Skin.

All of our Cells contain the identical Genetic Material to the first Cell that made us.
“Differential Gene Expression” is how that Cell gradually turned into the Cells of Skin, Heart, Pancreas, etc.

Now, suppose a person say, “A” has a certain disorder / disability say, “D”.

Suppose, the “D” disorder makes “A”‘s Motor Neurons shrink with time.

It would be “of limited view” to try to find out “the Gene” responsible for the disorder “D”.

Because each “Gene” that expresses itself through “Proteins” effects our body in different ways depending on in which part of the body the Protein is acting.

A particular “Gene” say, “G1” encoding certain Protein in our “Skin cell” might have different effect than

the same “G1” Gene encoding the same “Protein” (but involved in a different “Gene Regulatory Network”) in our “Motor Neuron”.

A better approach is to consider the effect of “Network of Genes” involved in a certain “Gene Regulatory Network”.

“Network of Genes” involved in different “Gene Regulatory Network”s express themselves to structure our Phenotype (and also our “Disorders” and “Disabilities”).

 

As we can see, Biologists should always keep in mind that:

“It’s not a single Gene that cause a certain Disorder, but ‘A Network of Genes’ involved in a certain “Gene Regulatory Network” that do.”

 

“A Network of Genes” translated into Proteins 

(a Protein itself could be defective or it could be “A wrong set of Proteins”) 

interacting in less-than-normal ways with other Proteins and Molecules

– From a macro perspective we classify this misbehavior as one of the (already classified) Disorders.

 – This is a “Molecular definition” of Diseases and Disorders.

#MolecularMedicine

 

Then why do Biologists approach “Molecular Medicine” this way (the Current approach):

“Let’s gather Genomic Data of as many persons as we can with “X” disorder and find similarities in their Genomes to find out which “Gene”s could be responsible for the “X” disorder”

The reason: Biology as a Science, is yet to mature.
Biologists still struggle to find out which Genes encode which Protein with a certain feature.

 

We are still far from complete understanding of:

Gene ->  Differential Gene Expression ->  Phenotype / Disorder / Disabilities.

Our current approach is to find out:

Gene  ->  Disorder / Disabilities.

“Let’s get as many people as we can with a certain Disorder and search their Genome to find the “Gene” responsible for the “Disorder”.

an approach which, as I have explained, is limited.

 

Areas of Expertise:  

#Molecular Medicine

#Computational & Systems Biology (CSB)

#BioEngineering

#Medicine  #Medical Sciences